Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

Most E3 ligases use a RING domain to activate a thioester-linked E2~ubiquitin-like protein (UBL) intermediate and promote UBL transfer to a remotely bound target protein. Nonetheless, RING E3 mechanisms matching a specific UBL and acceptor lysine remain elusive, including for RBX1, which mediates NE...

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Udgivet i:Cell
Main Authors: Scott, Daniel C., Sviderskiy, Vladislav O., Monda, Julie K., Lydeard, John R., Cho, Shein Ei, Harper, J. Wade, Schulman, Brenda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247792/
https://ncbi.nlm.nih.gov/pubmed/24949976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.04.037
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