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NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Virtually all eukaryotic processes are regulated by cullin-RING E3 ligase (CRL)-catalyzed protein ubiquitylation(1), which is exquisitely controlled by cullin modification with the ubiquitin (UB)-like protein NEDD8(2–6). However, how CRLs catalyze ubiquitylation, and the basis for NEDD8 activation,...
Shranjeno v:
| izdano v: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7050210/ https://ncbi.nlm.nih.gov/pubmed/32051583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2000-y |
| Oznake: |
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