NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly

Virtually all eukaryotic processes are regulated by cullin-RING E3 ligase (CRL)-catalyzed protein ubiquitylation(1), which is exquisitely controlled by cullin modification with the ubiquitin (UB)-like protein NEDD8(2–6). However, how CRLs catalyze ubiquitylation, and the basis for NEDD8 activation,...

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Bibliografiska uppgifter
I publikationen:Nature
Huvudupphovsmän: Baek, Kheewoong, Krist, David T., Prabu, J. Rajan, Hill, Spencer, Klügel, Maren, Neumaier, Lisa-Marie, von Gronau, Susanne, Kleiger, Gary, Schulman, Brenda A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050210/
https://ncbi.nlm.nih.gov/pubmed/32051583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2000-y
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