Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates(1,2). However, rather than functioning individually, many neddylated cullin–RING E3 ligases (CRLs) and RBR-type E3 liga...

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Publicado no:Nature
Main Authors: Horn-Ghetko, Daniel, Krist, David T., Prabu, J. Rajan, Baek, Kheewoong, Mulder, Monique P. C., Klügel, Maren, Scott, Daniel C., Ovaa, Huib, Kleiger, Gary, Schulman, Brenda A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904520/
https://ncbi.nlm.nih.gov/pubmed/33536622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03197-9
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