Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

Protein ubiquitination is a core regulatory determinant of neural development. Previous studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN) and thereby regulate axonal growth in neurons. Using conditional knocko...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hsia, Hung-En, Kumar, Rohit, Luca, Rossella, Takeda, Michiko, Courchet, Julien, Nakashima, Jonathan, Wu, Shumin, Goebbels, Sandra, An, Wenlin, Eickholt, Britta J., Polleux, Franck, Rotin, Daniela, Wu, Hong, Rossner, Moritz J., Bagni, Claudia, Rhee, Jeong-Seop, Brose, Nils, Kawabe, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246980/
https://ncbi.nlm.nih.gov/pubmed/25157163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400737111
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