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The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
PTEN is a tumor suppressor frequently mutated in cancer. Recent reports implicated Nedd4-1 as the E3 ubiquitin ligase for PTEN that regulates its stability and nuclear localization. We tested the physiological role of Nedd4-1 as a PTEN regulator by using cells and tissues derived from two independen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438405/ https://ncbi.nlm.nih.gov/pubmed/18562292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803233105 |
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