Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease

Cystic fibrosis is caused by impaired ion transport due to mutated cystic fibrosis transmembrane conductance regulator, accompanied by elevated activity of the amiloride-sensitive epithelial Na(+) channel (ENaC). Here we show that knockout of the ubiquitin ligase Nedd4L (Nedd4-2) specifically in lun...

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Detalhes bibliográficos
Main Authors: Kimura, Toshihiro, Kawabe, Hiroshi, Jiang, Chong, Zhang, Wenbo, Xiang, Yun-Yan, Lu, Chen, Salter, Michael W., Brose, Nils, Lu, Wei-Yang, Rotin, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044364/
https://ncbi.nlm.nih.gov/pubmed/21300902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010334108
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