The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

PTEN is a tumor suppressor frequently mutated in cancer. Recent reports implicated Nedd4-1 as the E3 ubiquitin ligase for PTEN that regulates its stability and nuclear localization. We tested the physiological role of Nedd4-1 as a PTEN regulator by using cells and tissues derived from two independen...

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Detaylı Bibliyografya
Asıl Yazarlar: Fouladkou, Fatemeh, Landry, Tamara, Kawabe, Hiroshi, Neeb, Antje, Lu, Chen, Brose, Nils, Stambolic, Vuk, Rotin, Daniela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438405/
https://ncbi.nlm.nih.gov/pubmed/18562292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803233105
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