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Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptor
We predicted the structural basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (GPCR) by predicting the binding of several ligands to the lower-energy conformations of the CCR5 receptor and 11 mutants. For each case, we predicted the ∼20 most stable conform...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246978/ https://ncbi.nlm.nih.gov/pubmed/25157173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413216111 |
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