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SuperBiHelix method for predicting the pleiotropic ensemble of G-protein–coupled receptor conformations
There is overwhelming evidence that G-protein–coupled receptors (GPCRs) exhibit several distinct low-energy conformations, each of which might favor binding to different ligands and/or lead to different downstream functions. Understanding the function of such proteins requires knowledge of the ensem...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890820/ https://ncbi.nlm.nih.gov/pubmed/24344284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321233111 |
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