Use of G-Protein-Coupled and -Uncoupled CCR5 Receptors by CCR5 Inhibitor-Resistant and -Sensitive Human Immunodeficiency Virus Type 1 Variants

Small-molecule CCR5 inhibitors such as vicriviroc (VVC) and maraviroc (MVC) are allosteric modulators that impair HIV-1 entry by stabilizing a CCR5 conformation that the virus recognizes inefficiently. Viruses resistant to these compounds are able to bind the inhibitor-CCR5 complex while also intera...

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Hlavní autoři: Berro, Reem, Yasmeen, Anila, Abrol, Ravinder, Trzaskowski, Bartosz, Abi-Habib, Sarya, Grunbeck, Amy, Lascano, Danny, Goddard, William A., Klasse, Per Johan, Sakmar, Thomas P., Moore, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676082/
https://ncbi.nlm.nih.gov/pubmed/23468486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00099-13
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