Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

RS67333 is a partial serotonin subtype 4 receptor (5-HT(4)R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Lecoutey, Cédric, Hedou, Damien, Freret, Thomas, Giannoni, Patrizia, Gaven, Florence, Since, Marc, Bouet, Valentine, Ballandonne, Céline, Corvaisier, Sophie, Malzert Fréon, Aurélie, Mignani, Serge, Cresteil, Thierry, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246933/
https://ncbi.nlm.nih.gov/pubmed/25157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410315111
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