Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

RS67333 is a partial serotonin subtype 4 receptor (5-HT(4)R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lecoutey, Cédric, Hedou, Damien, Freret, Thomas, Giannoni, Patrizia, Gaven, Florence, Since, Marc, Bouet, Valentine, Ballandonne, Céline, Corvaisier, Sophie, Malzert Fréon, Aurélie, Mignani, Serge, Cresteil, Thierry, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246933/
https://ncbi.nlm.nih.gov/pubmed/25157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410315111
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