Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

RS67333 is a partial serotonin subtype 4 receptor (5-HT(4)R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lecoutey, Cédric, Hedou, Damien, Freret, Thomas, Giannoni, Patrizia, Gaven, Florence, Since, Marc, Bouet, Valentine, Ballandonne, Céline, Corvaisier, Sophie, Malzert Fréon, Aurélie, Mignani, Serge, Cresteil, Thierry, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246933/
https://ncbi.nlm.nih.gov/pubmed/25157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410315111
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