Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

RS67333 is a partial serotonin subtype 4 receptor (5-HT(4)R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Lecoutey, Cédric, Hedou, Damien, Freret, Thomas, Giannoni, Patrizia, Gaven, Florence, Since, Marc, Bouet, Valentine, Ballandonne, Céline, Corvaisier, Sophie, Malzert Fréon, Aurélie, Mignani, Serge, Cresteil, Thierry, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246933/
https://ncbi.nlm.nih.gov/pubmed/25157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410315111
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