Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

RS67333 is a partial serotonin subtype 4 receptor (5-HT(4)R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lecoutey, Cédric, Hedou, Damien, Freret, Thomas, Giannoni, Patrizia, Gaven, Florence, Since, Marc, Bouet, Valentine, Ballandonne, Céline, Corvaisier, Sophie, Malzert Fréon, Aurélie, Mignani, Serge, Cresteil, Thierry, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246933/
https://ncbi.nlm.nih.gov/pubmed/25157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410315111
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