Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

The pyruvate dehydrogenase complex (PDH) has been hypothesized to link lipid exposure to skeletal muscle insulin resistance through a glucose-fatty acid cycle in which increased fatty acid oxidation increases acetyl-CoA concentrations, thereby inactivating PDH and decreasing glucose oxidation. Howev...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Rahimi, Yasmeen, Camporez, João-Paulo G., Petersen, Max C., Pesta, Dominik, Perry, Rachel J., Jurczak, Michael J., Cline, Gary W., Shulman, Gerald I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246337/
https://ncbi.nlm.nih.gov/pubmed/25368185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419104111
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