Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

The pyruvate dehydrogenase complex (PDH) has been hypothesized to link lipid exposure to skeletal muscle insulin resistance through a glucose-fatty acid cycle in which increased fatty acid oxidation increases acetyl-CoA concentrations, thereby inactivating PDH and decreasing glucose oxidation. Howev...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Rahimi, Yasmeen, Camporez, João-Paulo G., Petersen, Max C., Pesta, Dominik, Perry, Rachel J., Jurczak, Michael J., Cline, Gary W., Shulman, Gerald I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2014
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246337/
https://ncbi.nlm.nih.gov/pubmed/25368185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419104111
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