Reversal of Hypertriglyceridemia, Fatty Liver Disease and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

Non-alcoholic fatty liver disease (NAFLD) affects one in three Americans and is a major predisposing condition for type 2 diabetes (T2D), however there are currently no drugs available to treat this disease. We examined whether a functionally liver-targeted derivative of 2,4-dinitrophenol (DNP), DNP...

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Detalhes bibliográficos
Main Authors: Perry, Rachel J., Kim, Taehan, Zhang, Xian-Man, Lee, Hui-Young, Pesta, Dominik, Popov, Violeta B., Zhang, Dongyan, Rahimi, Yasmeen, Jurczak, Michael J., Cline, Gary W., Spiegel, David A., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104686/
https://ncbi.nlm.nih.gov/pubmed/24206666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.10.004
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