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Direct Determination of Multiple Ligand Interactions with the Extracellular Domain of the Calcium-sensing Receptor
Numerous in vivo functional studies have indicated that the dimeric extracellular domain (ECD) of the CaSR plays a crucial role in regulating Ca(2+) homeostasis by sensing Ca(2+) and l-Phe. However, direct interaction of Ca(2+) and Phe with the ECD of the receptor and the resultant impact on its str...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246106/ https://ncbi.nlm.nih.gov/pubmed/25305020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604652 |
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