Direct Determination of Multiple Ligand Interactions with the Extracellular Domain of the Calcium-sensing Receptor

Numerous in vivo functional studies have indicated that the dimeric extracellular domain (ECD) of the CaSR plays a crucial role in regulating Ca(2+) homeostasis by sensing Ca(2+) and l-Phe. However, direct interaction of Ca(2+) and Phe with the ECD of the receptor and the resultant impact on its str...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Chen, Zhuo, You, Moniz, Heather A., Wang, Shuo, Moremen, Kelley W., Prestegard, James H., Brown, Edward M., Yang, Jenny J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246106/
https://ncbi.nlm.nih.gov/pubmed/25305020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604652
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