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Binding site discovery from nucleic acid sequences by discriminative learning of hidden Markov models

We present a discriminative learning method for pattern discovery of binding sites in nucleic acid sequences based on hidden Markov models. Sets of positive and negative example sequences are mined for sequence motifs whose occurrence frequency varies between the sets. The method offers several obje...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Maaskola, Jonas, Rajewsky, Nikolaus
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245949/
https://ncbi.nlm.nih.gov/pubmed/25389269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1083
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