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Binding site discovery from nucleic acid sequences by discriminative learning of hidden Markov models

We present a discriminative learning method for pattern discovery of binding sites in nucleic acid sequences based on hidden Markov models. Sets of positive and negative example sequences are mined for sequence motifs whose occurrence frequency varies between the sets. The method offers several obje...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Maaskola, Jonas, Rajewsky, Nikolaus
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245949/
https://ncbi.nlm.nih.gov/pubmed/25389269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1083
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