Á lódáil...

Discovery of multiple hidden allosteric sites by combining Markov state models and experiments

The discovery of drug-like molecules that bind pockets in proteins that are not present in crystallographic structures yet exert allosteric control over activity has generated great interest in designing pharmaceuticals that exploit allosteric effects. However, there have only been a small number of...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Bowman, Gregory R., Bolin, Eric R., Hart, Kathryn M., Maguire, Brendan C., Marqusee, Susan
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352775/
https://ncbi.nlm.nih.gov/pubmed/25730859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417811112
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!