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Discovery of multiple hidden allosteric sites by combining Markov state models and experiments
The discovery of drug-like molecules that bind pockets in proteins that are not present in crystallographic structures yet exert allosteric control over activity has generated great interest in designing pharmaceuticals that exploit allosteric effects. However, there have only been a small number of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352775/ https://ncbi.nlm.nih.gov/pubmed/25730859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417811112 |
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