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Discovery of multiple hidden allosteric sites by combining Markov state models and experiments
The discovery of drug-like molecules that bind pockets in proteins that are not present in crystallographic structures yet exert allosteric control over activity has generated great interest in designing pharmaceuticals that exploit allosteric effects. However, there have only been a small number of...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352775/ https://ncbi.nlm.nih.gov/pubmed/25730859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417811112 |
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