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Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

Amyloid β-protein (Aβ) plays a central role in the pathogenesis of Alzheimer's disease, the most common age-associated neurodegenerative disorder. Aβ is generated through intramembrane proteolysis of the β-carboxyl terminal fragment (βCTF) of β-amyloid precursor protein (APP) by γ-secretase. Th...

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Bibliografiske detaljer
Udgivet i:Front Physiol
Hovedforfatter: Morishima-Kawashima, Maho
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245903/
https://ncbi.nlm.nih.gov/pubmed/25505888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00463
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