TGFβ1 Mediates Alcohol-Induced Nrf2 Suppression in Lung Fibroblasts

BACKGROUND: Chronic alcohol ingestion induces the expression of transforming growth factor beta-1(TGFβ1), inhibits nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated activation of the antioxidant response element (ARE), depletes alveolar glutathione pools, and potentiates acute lung injury....

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Publicat a:Alcohol Clin Exp Res
Autors principals: Sueblinvong, Viranuj, Tseng, Victor, Smith, Tierra, Saghafi, Ramin, Mills, Stephen T, Neujahr, David C, Guidot, David M
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Cell and Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244649/
https://ncbi.nlm.nih.gov/pubmed/25421510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12563
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