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MiR-21-mediated suppression of Smad7 induces TGFβ1 and can be inhibited by activation of Nrf2 in alcohol-treated lung fibroblasts

BACKGROUND: We previously demonstrated that chronic alcohol ingestion augments TGFβ1 expression in the lung fibroblast and increases the risk of fibroproliferative disrepair in a mouse model of acute lung injury. The effect of alcohol on TGFβ1 is mitigated by treatment with sulforaphane, which can a...

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Detalhes bibliográficos
Publicado no:Alcohol Clin Exp Res
Main Authors: Marts, Lucian T., Green, David E., Mills, Stephen T., Murphy, Tamara, Sueblinvong, Viranuj
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659938/
https://ncbi.nlm.nih.gov/pubmed/28888052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13496
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