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Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders

Choline acetyltransferase (ChAT) synthesizes acetylcholine in neurons and other cell types. Decreases in ChAT activity are associated with a number of disease states, and mutations in ChAT cause congenital neuromuscular disorders. The crystal structure of ChAT reported here shows the enzyme divided...

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Библиографические подробности
Главные авторы: Cai, Yiying, Cronin, Ciarán N, Engel, Andrew G, Ohno, Kinji, Hersh, Louis B, Rodgers, David W
Формат: Artigo
Язык:Inglês
Опубликовано: 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC424412/
https://ncbi.nlm.nih.gov/pubmed/15131697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600221
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