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Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection

BACKGROUND: The inflammasome is an intracellular protein complex triggered by exposure to intracellular pathogens, its components or other endogenous proteins. It leads to the activation of and subsequent release of proinflammatory cytokines such as IL-1β and IL-18. S. Typhimurium is a Gram-negative...

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Detalhes bibliográficos
Publicado no:BMC Immunol
Main Authors: De Jong, Hanna K, Koh, Gavin CKW, van Lieshout, Miriam HP, Roelofs, Joris JTH, van Dissel, Jaap T, van der Poll, Tom, Wiersinga, W Joost
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243774/
https://ncbi.nlm.nih.gov/pubmed/25115174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-014-0030-7
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