MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei.

BACKGROUND: Toll-like receptors (TLRs) have a central role in the recognition of pathogens and the initiation of the innate immune response. Myeloid differentiation primary-response gene 88 (MyD88) and TIR-domain-containing adaptor protein inducing IFNbeta (TRIF) are regarded as the key signaling ad...

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Bibliographic Details
Main Authors: W Joost Wiersinga, Catharina W Wieland, Joris J T H Roelofs, Tom van der Poll
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2566818?pdf=render
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