NMR of α-synuclein–polyamine complexes elucidates the mechanism and kinetics of induced aggregation

The aggregation of α-synuclein is characteristic of Parkinson's disease (PD) and other neurodegenerative synucleinopathies. The 140-aa protein is natively unstructured; thus, ligands binding to the monomeric form are of therapeutic interest. Biogenic polyamines promote the aggregation of α-synu...

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Bibliographic Details
Main Authors: Fernández, Claudio O, Hoyer, Wolfgang, Zweckstetter, Markus, Jares-Erijman, Elizabeth A, Subramaniam, Vinod, Griesinger, Christian, Jovin, Thomas M
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC424375/
https://ncbi.nlm.nih.gov/pubmed/15103328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600211
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