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NMR of α-synuclein–polyamine complexes elucidates the mechanism and kinetics of induced aggregation
The aggregation of α-synuclein is characteristic of Parkinson's disease (PD) and other neurodegenerative synucleinopathies. The 140-aa protein is natively unstructured; thus, ligands binding to the monomeric form are of therapeutic interest. Biogenic polyamines promote the aggregation of α-synu...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC424375/ https://ncbi.nlm.nih.gov/pubmed/15103328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600211 |
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