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Supramolecular Non-Amyloid Intermediates in the Early Stages of α-Synuclein Aggregation

The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate the early stages of the overall mechanism. The sequence of structural transformations between metastable intermediates were captured and...

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Autori principali: Fauerbach, Jonathan A., Yushchenko, Dmytro A., Shahmoradian, Sarah H., Chiu, Wah, Jovin, Thomas M., Jares-Erijman, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296045/
https://ncbi.nlm.nih.gov/pubmed/22404935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.051
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