Supramolecular Non-Amyloid Intermediates in the Early Stages of α-Synuclein Aggregation

The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate the early stages of the overall mechanism. The sequence of structural transformations between metastable intermediates were captured and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Fauerbach, Jonathan A., Yushchenko, Dmytro A., Shahmoradian, Sarah H., Chiu, Wah, Jovin, Thomas M., Jares-Erijman, Elizabeth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2012
Aiheet:
Protein
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296045/
https://ncbi.nlm.nih.gov/pubmed/22404935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.051
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