Supramolecular Non-Amyloid Intermediates in the Early Stages of α-Synuclein Aggregation

The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate the early stages of the overall mechanism. The sequence of structural transformations between metastable intermediates were captured and...

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Detalhes bibliográficos
Main Authors: Fauerbach, Jonathan A., Yushchenko, Dmytro A., Shahmoradian, Sarah H., Chiu, Wah, Jovin, Thomas M., Jares-Erijman, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296045/
https://ncbi.nlm.nih.gov/pubmed/22404935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.051
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