Supramolecular Non-Amyloid Intermediates in the Early Stages of α-Synuclein Aggregation

The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate the early stages of the overall mechanism. The sequence of structural transformations between metastable intermediates were captured and...

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Main Authors: Fauerbach, Jonathan A., Yushchenko, Dmytro A., Shahmoradian, Sarah H., Chiu, Wah, Jovin, Thomas M., Jares-Erijman, Elizabeth A.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2012
Teme:
Protein
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296045/
https://ncbi.nlm.nih.gov/pubmed/22404935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.051
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