Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in an AQP11 Knockout Model

We previously reported that disruption of the aquaporin-11 (AQP11) gene in mice resulted in cystogenesis in the kidney. In this study, we aimed to clarify the mechanism of cystogenesis in AQP11(−/−) mice. To enable the analyses of AQP11 at the protein level in vivo, AQP11 BAC transgenic mice (Tg(AQP...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Inoue, Yuichi, Sohara, Eisei, Kobayashi, Katsuki, Chiga, Motoko, Rai, Tatemitsu, Ishibashi, Kenichi, Horie, Shigeo, Su, Xuefeng, Zhou, Jing, Sasaki, Sei, Uchida, Shinichi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2014
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243341/
https://ncbi.nlm.nih.gov/pubmed/24854278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013060614
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