BRCA1 haploinsufficiency for replication stress suppression in primary cells

BRCA1—a breast and ovarian cancer suppressor gene—promotes genome integrity. To study the functionality of BRCA1 in the heterozygous state, we established a collection of primary human BRCA1(+/+) and BRCA1(mut/+) mammary epithelial cells and fibroblasts. Here we report that all BRCA1(mut/+) cells ex...

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Pubblicato in:Nat Commun
Autori principali: Pathania, Shailja, Bade, Sangeeta, Le Guillou, Morwenna, Burke, Karly, Reed, Rachel, Bowman-Colin, Christian, Su, Ying, Ting, David T., Polyak, Kornelia, Richardson, Andrea L., Feunteun, Jean, Garber, Judy E., Livingston, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243249/
https://ncbi.nlm.nih.gov/pubmed/25400221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6496
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