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Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle

Endogenous BRCA1 p220 expression peaks in S and G2 when it is activated, and the protein participates in certain key DNA damage responses. In contrast, its expression is markedly reduced in G0/G1. While variations in transcription represent a significant part of p220 expression control, there is at...

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Главные авторы: Dimitrov, Stoil D., Lu, David, Naetar, Nana, Hu, Yiduo, Pathania, Shailja, Kanellopoulou, Chryssa, Livingston, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814647/
https://ncbi.nlm.nih.gov/pubmed/24142877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.225045.113
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