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Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle
Endogenous BRCA1 p220 expression peaks in S and G2 when it is activated, and the protein participates in certain key DNA damage responses. In contrast, its expression is markedly reduced in G0/G1. While variations in transcription represent a significant part of p220 expression control, there is at...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814647/ https://ncbi.nlm.nih.gov/pubmed/24142877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.225045.113 |
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