BRCA1/FANCD2/BRG1-driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells

An abnormal differentiation state is common in BRCA1-deficient mammary epithelial cells, but the underlying mechanism is unclear. Here we report a convergence between DNA repair and normal, cultured human mammary epithelial (HME) cell differentiation. Surprisingly, depleting BRCA1 or FANCD2 (Fanconi...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wang, Hua, Bierie, Brian, Li, Andrew G., Pathania, Shailja, Toomire, Kimberly, Dimitrov, Stoil D, Liu, Ben, Gelman, Rebecca, Giobbie-Hurder, Anita, Feunteun, Jean, Polyak, Kornelia, Livingston, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982517/
https://ncbi.nlm.nih.gov/pubmed/27373334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.038
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