Crystal structure of the sodium–proton antiporter NhaA dimer and new mechanistic insights

Sodium–proton antiporters rapidly exchange protons and sodium ions across the membrane to regulate intracellular pH, cell volume, and sodium concentration. How ion binding and release is coupled to the conformational changes associated with transport is not clear. Here, we report a crystal form of t...

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Veröffentlicht in:J Gen Physiol
Hauptverfasser: Lee, Chiara, Yashiro, Shoko, Dotson, David L., Uzdavinys, Povilas, Iwata, So, Sansom, Mark S.P., von Ballmoos, Christoph, Beckstein, Oliver, Drew, David, Cameron, Alexander D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242812/
https://ncbi.nlm.nih.gov/pubmed/25422503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411219
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