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Stargazin promotes closure of the AMPA receptor ligand-binding domain

Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown. Here we find that the...

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Bibliographische Detailangaben
Veröffentlicht in:J Gen Physiol
Hauptverfasser: MacLean, David M., Ramaswamy, Swarna S., Du, Mei, Howe, James R., Jayaraman, Vasanthi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242809/
https://ncbi.nlm.nih.gov/pubmed/25422502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411287
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