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A Membrane Proximal Helix in the Cytosolic Domain of the Human APP Interacting Protein LR11/SorLA Deforms Liposomes

Over the last decade, compelling evidence has linked the development of Alzheimer’s disease (AD) to defective intracellular trafficking of the amyloid precursor protein (APP). Faulty APP trafficking results in an overproduction of Aβ peptides, which is generally agreed to be the primary cause of AD-...

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Pubblicato in:Biochim Biophys Acta
Autori principali: Gill, Richard L., Wang, Xingsheng, Tian, Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242801/
https://ncbi.nlm.nih.gov/pubmed/24866012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.05.020
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