A Membrane Proximal Helix in the Cytosolic Domain of the Human APP Interacting Protein LR11/SorLA Deforms Liposomes

Over the last decade, compelling evidence has linked the development of Alzheimer’s disease (AD) to defective intracellular trafficking of the amyloid precursor protein (APP). Faulty APP trafficking results in an overproduction of Aβ peptides, which is generally agreed to be the primary cause of AD-...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Gill, Richard L., Wang, Xingsheng, Tian, Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242801/
https://ncbi.nlm.nih.gov/pubmed/24866012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.05.020
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