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Stability of Iowa mutant and wild type Aβ-peptide aggregates

Recent experiments indicate a connection between the structure of amyloid aggregates and their cytotoxicity as related to neurodegenerative diseases. Of particular interest is the Iowa Mutant, which causes early-onset of Alzheimer's disease. While wild-type Amyloid β-peptides form only parallel...

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Udgivet i:J Chem Phys
Main Authors: Alred, Erik J., Scheele, Emily G., Berhanu, Workalemahu M., Hansmann, Ulrich H. E.
Format: Artigo
Sprog:Inglês
Udgivet: American Institute of Physics 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241800/
https://ncbi.nlm.nih.gov/pubmed/25381547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4900892
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