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Side-chain hydrophobicity and the stability of Aβ(16–22) aggregates
Recent mutagenesis studies using the hydrophobic segment of Aβ suggest that aromatic π-stacking interactions may not be critical for fibril formation. We have tested this conjecture by probing the effect of Leu, Ile, and Ala mutation of the aromatic Phe residues at positions 19 and 20, on the double...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575914/ https://ncbi.nlm.nih.gov/pubmed/23015407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2164 |
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