TCF7L2 is a master regulator of insulin production and processing

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet functi...

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Bibliografiska uppgifter
I publikationen:Hum Mol Genet
Huvudupphovsmän: Zhou, Yuedan, Park, Soo-Young, Su, Jing, Bailey, Kathleen, Ottosson-Laakso, Emilia, Shcherbina, Liliya, Oskolkov, Nikolay, Zhang, Enming, Thevenin, Thomas, Fadista, João, Bennet, Hedvig, Vikman, Petter, Wierup, Nils, Fex, Malin, Rung, Johan, Wollheim, Claes, Nobrega, Marcelo, Renström, Erik, Groop, Leif, Hansson, Ola
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240194/
https://ncbi.nlm.nih.gov/pubmed/25015099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu359
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