TCF7L2 is a master regulator of insulin production and processing

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet functi...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Zhou, Yuedan, Park, Soo-Young, Su, Jing, Bailey, Kathleen, Ottosson-Laakso, Emilia, Shcherbina, Liliya, Oskolkov, Nikolay, Zhang, Enming, Thevenin, Thomas, Fadista, João, Bennet, Hedvig, Vikman, Petter, Wierup, Nils, Fex, Malin, Rung, Johan, Wollheim, Claes, Nobrega, Marcelo, Renström, Erik, Groop, Leif, Hansson, Ola
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240194/
https://ncbi.nlm.nih.gov/pubmed/25015099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu359
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