Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Genetic variation can modulate gene expression, and thereby phenotypic variation and susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the potential of DNA and RNA sequencing in human pancreatic islets from 89 deceased donors to identify genes of potential importanc...

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Bibliografiska uppgifter
Huvudupphovsmän: Fadista, João, Vikman, Petter, Laakso, Emilia Ottosson, Mollet, Inês Guerra, Esguerra, Jonathan Lou, Taneera, Jalal, Storm, Petter, Osmark, Peter, Ladenvall, Claes, Prasad, Rashmi B., Hansson, Karin B., Finotello, Francesca, Uvebrant, Kristina, Ofori, Jones K., Di Camillo, Barbara, Krus, Ulrika, Cilio, Corrado M., Hansson, Ola, Eliasson, Lena, Rosengren, Anders H., Renström, Erik, Wollheim, Claes B., Groop, Leif
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183326/
https://ncbi.nlm.nih.gov/pubmed/25201977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402665111
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