TCF7L2 is a master regulator of insulin production and processing

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet functi...

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Опубликовано в: :Hum Mol Genet
Главные авторы: Zhou, Yuedan, Park, Soo-Young, Su, Jing, Bailey, Kathleen, Ottosson-Laakso, Emilia, Shcherbina, Liliya, Oskolkov, Nikolay, Zhang, Enming, Thevenin, Thomas, Fadista, João, Bennet, Hedvig, Vikman, Petter, Wierup, Nils, Fex, Malin, Rung, Johan, Wollheim, Claes, Nobrega, Marcelo, Renström, Erik, Groop, Leif, Hansson, Ola
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240194/
https://ncbi.nlm.nih.gov/pubmed/25015099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu359
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