AMPylation of Rho GTPases Subverts Multiple Host Signaling Processes

Rho GTPases are frequent targets of virulence factors as they are keystone signaling molecules. Herein, we demonstrate that AMPylation of Rho GTPases by VopS is a multifaceted virulence mechanism that counters several host immunity strategies. Activation of NFκB, Erk, and JNK kinase signaling pathwa...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Woolery, Andrew R., Yu, Xiaobo, LaBaer, Joshua, Orth, Kim
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239643/
https://ncbi.nlm.nih.gov/pubmed/25301945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601310
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