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Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies
Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting states. By contrast, during times of stress, BiP is deAMPylated. Here, we show that excessive AMPylation by a constitu...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743091/ https://ncbi.nlm.nih.gov/pubmed/29089387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.799296 |
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