Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies

Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting states. By contrast, during times of stress, BiP is deAMPylated. Here, we show that excessive AMPylation by a constitu...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei, Servage, Kelly A., Krämer, Helmut, Orth, Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743091/
https://ncbi.nlm.nih.gov/pubmed/29089387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.799296
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