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Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways, the Unfolded Protein Response protects cells from the accumulation of misfolded proteins in the ER. Depending on ER stress levels, the ER-resid...

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Publicado en:eLife
Autores principales: Moehlman, Andrew T, Casey, Amanda K, Servage, Kelly, Orth, Kim, Krämer, Helmut
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066327/
https://ncbi.nlm.nih.gov/pubmed/30015618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38752
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