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Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways, the Unfolded Protein Response protects cells from the accumulation of misfolded proteins in the ER. Depending on ER stress levels, the ER-resid...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Moehlman, Andrew T, Casey, Amanda K, Servage, Kelly, Orth, Kim, Krämer, Helmut
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066327/
https://ncbi.nlm.nih.gov/pubmed/30015618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38752
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