Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket

Pathogenic mutations in the LRRK2 gene can cause late-onset Parkinson disease. The most common mutation, G2019S, resides in the kinase domain and enhances activity. LRRK2 possesses the unique property of cis-autophosphorylation of its own GTPase domain. Because high-resolution structures of the huma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Zhiyong, Galemmo, Robert A., Fraser, Kyle B., Moehle, Mark S., Sen, Saurabh, Volpicelli-Daley, Laura A., DeLucas, Lawrence J., Ross, Larry J., Valiyaveettil, Jacob, Moukha-Chafiq, Omar, Pathak, Ashish K., Ananthan, Subramaniam, Kezar, Hollis, White, E. Lucile, Gupta, Vandana, Maddry, Joseph A., Suto, Mark J., West, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239640/
https://ncbi.nlm.nih.gov/pubmed/25228699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602318
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